منابع مشابه
The Indirect Inhibition of Protein Synthesis in Vivo by Chlorpromazine.
The inhibition of protein synthesis in the brains of rats treated with chlorpromazine has been reported by Piha, Oja, and Usitalio (1) and by Glasky (2). In agreement with these observations, we were able to inhibit the incorporation of labeled amino acids into the brain proteins of mice by treating the animals with chlorpromazine. However, we were unable to demonstrate inhibition of the incorp...
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Two forms of radiolabeled creatinine were used in this study, [carbonyl-14C]- and [amidino-14C]creatinine, the latter being synthesized in this laboratory. These labeled compounds were given intravenously to rabbits. Specimens of plasma, urine, feces, and selected tissues were collected. These were liquid-chromatographed and the separated components compared for radioactivity and identity. This...
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The aim of the present study was to investigate the possible effects of antidepressant drugs (fluvoxamine, imipramine) on the metabolism of the aliphatic-type phenothiazine neuroleptic chlorpromazine in the human liver. The experiment was performed in vitro using human liver microsomes. The kinetic analysis of chlorpromazine metabolism carried out in the absence or presence of antidepressants s...
متن کاملCentral actions of chlorpromazine.
It was synthesized by M/s Rhone Poulence Laboratories of Paris, to meet the demand for a drug that will be effective in the prcvention and/or treatment of surgical shock, This was sought to be achicved by damping out the homeostalic regulating reactions including those under the control of the hypothalamus, by Ihe use of a suitable pharmacodynamic agent, supplemented by induced hypothermia. CPZ...
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Forty-four hospitalized schizophrenic patients, 22 in each of two groups, were treated for a period of 6 weeks with either EGT-GPZ combination or CPZ alone. Ratings on RP scale (Rockland and Pollin, 1S65) showed that the KGT-receiving group was significantly better en several measure at second week and also had an earlier onset of beneficial response on "Affect and Mood." However, at the end of...
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ژورنال
عنوان ژورنال: Canadian Psychiatric Association Journal
سال: 1966
ISSN: 0008-4824
DOI: 10.1177/070674376601100405